Halfway by his profession, Cees Dekker reinvented himself. Just after several years of hardcore physics, he shifted his focus to ‘nanobiology’ with the turn on the millennium. A term he coined himself, being a matter of truth.
Our group research bacterial mobile division which is aiming to constitute a ‘bottom up biology’ in artificial cells which will autonomously divide. Our major curiosity lies in cell division, chromatin composition, and spatial Regulate.
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Deposition and atomic drive microscopy of particular person phthalocyanine polymers involving nanofabricated electrodes
2010, developed a brand new way (‘wedging transfer’) to control nanostructures; 1st report of DNA translocation via graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into reliable-condition nanopores
Our investigation ranges through the biophysics of DNA to artificial cells and over and above. Remember to have a look beneath in the spectrum of our present tasks.
Numerous connected developments followed, exactly where our group set up various transistor variants like single-electron transistors at area temperature and intramolecular nanotube junctions that acted as ceesdekker.net rectifying diodes, and coupled a number of transistors into modest proof-of-theory electronic circuits.
Learning DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.
The rotors harness Electrical power from a nanoscale water and ion move that is certainly generated by a static chemical or electrochemical opportunity gradient from the nanopore, which can be proven via a salt gradient or utilized voltage, respectively. These artificial nanoengines self-Arrange and operate autonomously in physiological disorders, suggesting strategies to constructing Electrical power-transducing motors at nanoscale interfaces.
There was one particular dilemma while — we didn't notice any measurable electrical conduction from The one polymer molecules. We concluded that at The one-molecule amount, conducting polymers were being actually not this kind of excellent conductors, which was relatively disappointing. We As a result broadened our watch to test to seek out far more promising molecules.
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
‘That fears the synthetic mobile, as part of the Dutch BaSyC initiative. Craig Venter seemed top rated-down in These times and discovered about five hundred genes which might be minimally required for any performing cell. We want to seem base-up: how do we transfer from the couple molecules to a complete biological process?
Visualization of unstained DNA nanostructures with Sophisticated in-target transmission electron microscopy approaches
Good-point out nanopores have tested to generally be a surprisingly versatile probe for single-molecule analysis of DNA. I'll explain several of our new results – exclusively DNA knots – and our endeavours to extend the abilities of stable-condition nanopores even more, inside the path of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.