Applying solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic components of the framework and dynamics of chromosomes. Our investigation interests incorporate:
1996, first mesoscopic cost density waves equipment; and initial electrical measurements on one metallic nanocluster in between nanoelectrodes
Throughout the exact same time, the team of Paul McEuen, who was then dependent for the College of California, Berkeley, showed related effects on ropes of bundled nanotubes. Depending upon the wrapping angle, nanotubes can are available in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard College independently verified utilizing scanning tunnelling spectroscopy experiments.
Deposition and atomic power microscopy of personal phthalocyanine polymers in between nanofabricated electrodes
We develop issue-of-treatment diagnostics check of neglected tropical illnesses within useful resource-constrained settings, dependant on Crspr/Cas9 detecting of pathogen’s DNA in overall body fluids.
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
What distinguishes biology from chemistry is the fact these elements alongside one another make up a living procedure. The secret of reported existence, I do think, lies inside the interactions, the interaction of These molecules. The large question with regards to the origin of lifestyle continues to be unanswered. How did we at any time evolve from simple molecules to the exceptionally intricate techniques we see now? We don't know. I would like to operate on These types of large, open queries.’
Nanopores signify a sublime and functional Software to evaluate one molecules. We exploration novel detection modes with stable-point out nanopores and various ways to evaluate proteins with nanopores. Jobs encompass the subsequent:
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Bulk-surface area coupling identifies the mechanistic link involving Min-protein styles in vivo As well as in vitro
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2008, initial observation of protein-coated DNA translocation via nanopores; resolved the origin of the electrophoretic force on DNA in nanopores; discovered a significant velocity increase of microtubules in electric fields; discovered an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
Instance (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim with the pore is highlighted in crimson, and a 3D rendering with the motion on the DNA rod is displayed.